Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?
The Korean Journal of Internal Medicine
; : 206-215, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-123030
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
To compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evaluate risk factors for MetS and increased HOMA-IR in patients with RA.METHODS:
In a cross-sectional setting, 84 female patients with RA and 109 age-matched healthy female subjects were consecutively recruited at a university-affiliated rheumatology center in South Korea. MetS was defined according to the Third Report of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP III) 2004 criteria.RESULTS:
The frequency of MetS did not differ significantly between patients with RA (19%) and healthy subjects (15.6%, p = 0.566), although patients with RA had a higher HOMA-IR compared with healthy subjects (p < 0.001). Patients with RA met the NCEP-ATP III 2004 criteria for high blood pressure more often than healthy subjects (44% vs. 19.3%, p < 0.001), and low high density lipoprotein cholesterol was more prevalent in healthy subjects (33%) than in patients with RA (14.3%, p = 0.004). Although no obvious risk factors for the presence of MetS were identified in patients with RA, higher serum C-reactive protein and disease activity score assessed using the 28-joint count for swelling and tenderness-erythrocyte sedimentation rate significantly contributed to a higher HOMA-IR.CONCLUSIONS:
Despite their increased insulin resistance, South Korean women with RA did not have a significantly higher frequency of MetS compared with that in healthy subjects.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Insulin Resistance
/
Biomarkers
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Case-Control Studies
/
Chi-Square Distribution
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Linear Models
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Logistic Models
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Odds Ratio
/
Sex Factors
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Prevalence
Type of study:
Etiology study
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Observational study
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Prevalence study
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Prognostic study
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Risk factors
Limits:
Adult
/
Aged
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Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2013
Document type:
Article