GSTM1 Tissue Genotype as a Recurrence Predictor in Non-muscle Invasive Bladder Cancer
Journal of Korean Medical Science
; : 231-236, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-123286
Responsible library:
WPRO
ABSTRACT
Tissue genotyping is more useful approach than using blood genomic DNA, which can reflect the effects of the somatic mutations in cancer. Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC) development, few reports provide information about the prognosis of BC. We investigated glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genotypes using genomic DNA from primary 165 BC tissue samples to assess the association with disease prognosis. DNA samples from tumor were analyzed by multiplex polymerase chain reaction (PCR). The results were compared with clinicopathological parameters. The prognostic significance of the GSTs was evaluated by Kaplan-Meier and multivariate Cox regression model. Kaplan-Meier estimates revealed significant differences in time to tumor recurrence according to the GSTM1 tissue genotype (P = 0.038) in non-muscle invasive bladder cancer (NMIBC). Multivariate Cox regression analysis also revealed that the tissue GSTM1 genotype (hazards ratio [HR] 0.377, P = 0.031) was an independent predictor of bladder tumor recurrence in NMIBC. This identification of GSTM1 tissue genotype as a prognosticator for determining recurrence in NMIBC should prove highly useful in a clinical setting.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Urinary Bladder Neoplasms
/
Biomarkers, Tumor
/
Proportional Hazards Models
/
Kaplan-Meier Estimate
/
Genotype
/
Glutathione Transferase
/
Isoenzymes
Type of study:
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Document type:
Article