Neurologic Complications after Hematopoietic Stem Cell Transplantation in Children / 소아과
Korean Journal of Pediatrics
; : 978-985, 2004.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-124567
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Neurologic complications(NC) after hematopoietic stem cell transplantation(HSCT) are important because of high mortality and severe sequelae. We analyzed the incidence, manifestation and risk factors of NC in 61 children undergoing HSCT.METHODS:
We retrospectively analyzed NC in 61 cases(42 male and 19 female, aged one to 16 years) given HSCT between 1996 and 2003 due to hematologic malignacies, solid tumors, or other hematologic diseases.RESULTS:
NC were seen in 22 children(36.0%). Herpes zoster was the most frequent one(n=17, 27.9 %), followed by seizure(n=8, 13.1%), CNS infection(n=3, 4.9%), cyclosporin toxicity(n=3, 4.9%), CVA (n=2, 3.3%), and chemotherapy injury(n=1, 1.6%). Among the 22 cases, 12 developed herpes zoster only and 10 developed other NC in addition to herpes zoster. Two patients died of NC. The incidence of NC was not affected by various factors, including type and source of HSCT or previous cranial radiation.CONCLUSION:
NC were frequent in children who underwent HSCT. We should acknowlege the occurrence of various NC after HSCT. Further study is needed to develop measures to minimize these complications.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
Database:
WPRIM (Western Pacific)
Main subject:
Incidence
/
Risk Factors
/
Mortality
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2004
Document type:
Article