The Effect of Gamma-Glutamyltransferase on Impaired Fasting Glucose or Type 2 Diabetes in Korean Men / 당뇨병
Korean Diabetes Journal
; : 215-224, 2009.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-124698
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
We sought to determine the association between serum gamma-glutamyltransferase (GGT) levels within the normal range and the risk for development of impaired fasting glucose (IFG) or type 2 diabetes.METHODS:
This retrospective cohort study spanned four years (2002~2006) with 1,717 Korean men who underwent periodic health examinations at a university hospital in Incheon, Korea and were not diagnosed with IFG or type 2 diabetes. Fasting plasma glucose levels were measured at the annual health examination. IFG and diabetes were defined as a serum fasting glucose concentration of 100~125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between serum GGT levels and development of IFG or type 2 diabetes.RESULTS:
There was a strong dose-response relationship between serum GGT levels and the incidence of IFG and diabetes. A total of 570 cases (33.2%) of incident IFG and 50 cases (2.9%) of diabetes were found. After controlling potential predictors, the relative risks for the incidence of IFG for GGT levels or = 51 were 1.00, 0.99, 1.17, 1.23 and 1.38 respectively (P for trend 0.015), and for the incidence of diabetes were 1.00, 1.44, 1.80, 2.55 and 2.58 respectively (P for trend 0.050).CONCLUSION:
The risk for development of IFG and type 2 diabetes increased in a dose-dependent manner as serum GGT increased within its normal range in Korean men.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Reference Values
/
Proportional Hazards Models
/
Incidence
/
Retrospective Studies
/
Cohort Studies
/
Fasting
/
Glucose Intolerance
/
Diabetes Mellitus, Type 2
/
Gamma-Glutamyltransferase
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Diabetes Journal
Year:
2009
Document type:
Article