Differential Expression of Hypoxia Inducible Factor-1 alpha and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas
Journal of Korean Medical Science
; : 196-203, 2003.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-126082
Responsible library:
WPRO
ABSTRACT
This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1 alpha (HIF-1 alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell lung carcinomas (NSCLCs). We performed immunohistochemical stains using paraffin-embedded tissue blocks from 84 cases of operable NSCLC [No. of squamous cell carcinoma (SCC), 45; No. of adenocarcinoma (AC), 39]. HIF-1 alpha expression was related with histologic types (66.7% in SCCs vs 20.5% in ACs, p0.05, respectively). As for the histologic types, MVD and PCNA index were significantly higher in SCCs than in ACs (p=0.009 and p=0.016, respectively). Among HIF-1 alpha positive carcinomas, MVD was significantly higher in HIF-1 alpha positive SCCs than in HIF-1 alpha positive ACs (p=0.023). The overall survival curves were not associated with HIF-1 alpha expression or any other histologic parameters (p>0.05). These findings suggest that HIF-1 alpha expression in NSCLCs may play a differential role according to histologic types, but its prognostic significance is indeterminate.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Cell Division
/
Survival Rate
/
Carcinoma, Non-Small-Cell Lung
/
Proliferating Cell Nuclear Antigen
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Antigens, CD34
/
Vascular Endothelial Growth Factor A
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2003
Document type:
Article