The Interplay between Autophagy and Aging
Diabetes & Metabolism Journal
; : 333-339, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-130788
Responsible library:
WPRO
ABSTRACT
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Starvation
/
Aging
/
Organelles
/
Proteins
/
Reactive Oxygen Species
/
Cytoprotection
/
Caloric Restriction
/
Mitochondria
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2013
Document type:
Article