Leptin:Adiponectin Ratio and Metabolic Syndrome in the General Japanese Population / 대한진단검사의학회지

ABSTRACT

BACKGROUND: Circulating leptinadiponectin ratio (LA) is a potential surrogate marker for cardiometabolic diseases; however, the relationship of the LA with the occurrence of metabolic syndrome (MetS) has not yet been fully explored in the general Japanese population. METHODS: We enrolled 678 Japanese subjects (208 men and 470 women, mean age 58.8+/-14.4 [SD] yr; mean body mass index 23.6+/-3.3 kg/m2) in this study, and determined their MetS status by using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) recommendations with minor modifications for the Japanese population. Biochemical markers such as leptin and adiponectin present in blood were measured. The statistical analyses performed were gender-based. RESULTS: A in subjects with MetS was significantly higher than that in subjects without MetS, regardless of gender. The LA also showed a significant and gradual increase corresponding to the increase in the number of components of MetS present in both the genders (trend P<0.01). The cut-off level of the LA to detect MetS was 0.59 (sensitivity 0.72, specificity 0.70) in men and 1.04 (sensitivity 0.72, specificity 0.69) in women. CONCLUSIONS: These results suggest that the LA can serve as a clinically useful marker for detecting MetS characteristics in the general Japanese population. The clinical application of this laboratory index for detecting MetS should be assessed in future studies.