Dermatomyositis in a Patient with Cholangiocarcinoma Detected by an 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scan / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 848-852, 2016.
Article
in En
| WPRIM
| ID: wpr-132152
Responsible library:
WPRO
ABSTRACT
Cholangiocarcinoma with paraneoplastic dermatomyositis (DM) is extremely rare, and the whole body positron emission tomography-computed tomography (PET-CT) finding of paraneoplastic DM is rarely reported. We report a 66-year-old woman with metastatic cholangiocarcinoma, initially presented with bilateral proximal muscle uptake on PET-CT without clinical muscle symptoms. The initial interpretation of the high muscle uptake was metastasis to the muscles. However, while awaiting for chemotherapy, muscle weakness evolved and rapidly progressed. The level of creatine phosphokinase was significantly elevated. Electromyography revealed moderate myopathy, and a muscle biopsy showed degenerating myofibers with variable sizes. The diagnosis of paraneoplastic dermatomyositis was made. This case highlights that, although rare, paraneoplastic dermatomyositis can be present with cholangiocarcinoma. Also, muscle inflammation can precede the clinical muscle symptoms, and paraneoplastic DM should be considered as a possible differential diagnosis in the assessment of cancer patients who present with abnormal muscle tracer uptake in PET-CT scans.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Biopsy
/
Cholangiocarcinoma
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Muscle Weakness
/
Creatine Kinase
/
Positron-Emission Tomography
/
Dermatomyositis
/
Diagnosis
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Diagnosis, Differential
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Drug Therapy
/
Electromyography
Type of study:
Diagnostic_studies
Limits:
Aged
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Female
/
Humans
Language:
En
Journal:
Cancer Research and Treatment
Year:
2016
Document type:
Article