Prognosis of Recurrence after Complete Resection in Early-Stage Non-Small Cell Lung Cancer
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 449-456, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-13272
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Tumor recurrence is the most common cause of treatment failure, even after complete resection of early-stage non-small cell lung cancer (NSCLC). In this study, we investigated the prognosis of patients with early recurrence in order to identify independent risk factors related to early recurrence.METHODS:
Between February 1995 and December 2012, 242 patients who underwent surgical resection for stage I NSCLC at Dong-A University Hospital were reviewed. The factors predicting overall survival (OS) and early recurrence were investigated. We also investigated the relationship between the patterns and period of recurrence and clinicopathological factors.RESULTS:
For patients with stage IA and IB NSCLC, the 5-year OS rate was 75.7% and 57.3% (p=0.006), respectively. A multivariate Cox proportional hazards model demonstrated that gender (p=0.004), comorbidity number (p=0.038), resection type (p=0.002), and tumor size (p=0.022) were the statistically significant predictors of OS. Moreover, the multivariate analysis revealed that smoking history (p=0.023) and histologic grade (p=0.012) were the independent predictors of early recurrence. Additionally, only histologic grade (poor differentiation) was found to be significantly associated with a higher frequency of distant metastasis; there was no relationship between the patterns and period of recurrence and clinicopathological factors.CONCLUSION:
The present study demonstrated that smoking history and histologic grade were independent prognostic factors for early recurrence within two years in patients with early-stage NSCLC. Patients with these predictive factors may be good candidates for adjuvant therapy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Smoke
/
Smoking
/
Comorbidity
/
Proportional Hazards Models
/
Multivariate Analysis
/
Risk Factors
/
Treatment Failure
/
Carcinoma, Non-Small-Cell Lung
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2013
Document type:
Article