Maternal Plasma Hepatocyte Growth Factor Concentrations in Women Who Subsequently Developed Preeclampsia
Journal of Genetic Medicine
; : 78-83, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-137167
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aim of this nested case-control study was to investigate the association between hepatocyte growth factor (HGF) concentrations in maternal plasma and the risk of developing preeclampsia. MATERIALS ANDMETHODS:
Plasma HGF concentration were measured in 52 women who subsequently developed preeclampsia and 104 normal pregnant women at the time of genetic amniocentesis (15-20 weeks) by enzyme-linked immunosorbent assay.RESULTS:
Maternal plasma HGF concentrations were significantly higher in women with subsequent preeclampsia (median 737.8 ng/mL vs. 670.4 ng/mL, P=0.003) than in normal controls. However, HGF concentrations were not significantly different between subgroups by preeclamptic complications. After adjusting for potential confounding factors, women with HGF concentrations > or =702.5 ng/mL had a 3.2-fold increased risk (95% CI 2.7-5.4, P<0.001) of subsequent development of preeclampsia compared with women with HGF concentrations <702.5 ng/mL.CONCLUSION:
Elevated maternal plasma HGF concentrations in the early second-trimester are associated with an increased risk of developing preeclampsia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Pre-Eclampsia
/
Case-Control Studies
/
Risk Factors
/
Hepatocyte Growth Factor
/
Hepatocytes
/
Pregnant Women
/
Amniocentesis
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Genetic Medicine
Year:
2012
Document type:
Article