CREB-Phosphorylation as a Predictor of Therapeutic Response to Antidepressants
Journal of Korean Geriatric Psychiatry
; : 38-43, 2010.
Article
in Ko
| WPRIM
| ID: wpr-139197
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: CREB (c-AMP response element binding protein) is known as a key mediator of the therapeutic response to antidepressants. We investigated the change of CREB-phosphorylation (pCREB) at the early point of the fluoxetine treatment to find out it can be a predictor for antidepressant response. METHODS: We evaluated the pCREB of T - lymphocyte nuclear extracts from 18 depressed patients at 0 and 1th week during fluoxetine treatment (20 mg/day). Responders were defined as the > or = 50% reduction of HAM-D score in 4 weeks. We compared the changes of pCREB at 0 and 1th week between responders and non-responders. RESULTS: The responders showed a significant increase of pCREB at week 1 compared with week 0. The HAM-D difference between week 0 and 4 was positively correlated with the change of pCREB response. CONCLUSION: These results suggest that the early change of pCREB in peripheral lymphocyte can predict the later response of antidepressant. The correlation showed pCREB directly reflects a response status to the antidepressant fluoxetine and clinical improvement.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Lymphocytes
/
Fluoxetine
/
Response Elements
/
Depression
/
Antidepressive Agents
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Journal of Korean Geriatric Psychiatry
Year:
2010
Document type:
Article