Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis
Journal of Korean Medical Science
; : 1199-1204, 2014.
Article
in En
| WPRIM
| ID: wpr-140359
Responsible library:
WPRO
ABSTRACT
Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-alpha and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8+/-14.4 vs. 22.2+/-6.1 ng/mL; P or =2.6) were significantly higher than those in remission (DAS28<2.6) (36.45+/-14.36 vs. 24.63+/-8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-alpha and it may be a novel biomarker for assessing inflammatory activity in patients with RA.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Arthritis, Rheumatoid
/
Severity of Illness Index
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Blood Sedimentation
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C-Reactive Protein
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Enzyme-Linked Immunosorbent Assay
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Glycoproteins
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Biomarkers
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ROC Curve
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Tumor Necrosis Factor-alpha
/
Area Under Curve
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
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Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2014
Document type:
Article