Small Flat Adenocarcinoma of the Colon Arising From Familial Adenomatous Polyposis Patient: Suggesting de novo Origin
Journal of the Korean Society of Coloproctology
; : 655-660, 1998.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-14364
Responsible library:
WPRO
ABSTRACT
Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Colorectal Neoplasms
/
Adenocarcinoma
/
Adenoma
/
Colon
/
Colonic Neoplasms
/
Adenomatous Polyps
/
Adenomatous Polyposis Coli
/
Epithelial Cells
/
Epithelium
/
Carcinogenesis
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Coloproctology
Year:
1998
Document type:
Article