Panton-Valentine Leukocidin Positive Staphylococcus aureus Isolated from Blood in Korea / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 286-291, 2007.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-144489
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by some Staphylococcus aureus strains and associated with skin and soft tissue infections; these strains are epidemiologically associated with current outbreaks of community-acquired methicillin-resistant S. aureus (MRSA) and with necrotizing pneumonia in healthy adults in USA and Europe. This study was performed to investigate the presence of PVL-positive S. aureus and the significant infections known to be caused by this organism.METHODS:
A total of 573 strains of S. aureus blood isolates at university-affiliated hospital during 2002 to 2005 were selected. The presence of PVL was investigated using PCR. Additional 12 staphylococcal toxin genes were also examined in PVL-positive S. aureus strains, and MRSA isolates were typed for the staphylococcal cassette chromosome mec (SCCmec).RESULTS:
PVL genes were detected in 5 (0.9%) of 573 S. aureus strains, including 1 MRSA and 4 MSSA. The PVL-positive MRSA isolate was SCCmec type IV, and no other staphylococcal toxins were detected. The median age of the patients infected with PVL-positive S. aureus was 36 yr. Three cases of bacteremia were preceded by skin and soft-tissue infections.CONCLUSIONS:
Bacteremia caused by PVL-positive S. aureus strain were detected in 5 patients in Korea, and some of the patients were associated with severe skin and soft-tissue infections. In addition, the PVL-positive MRSA strain of SCCmec type IV, a characteristic of community-acquired MRSA isolates in USA and Europe, also exists in Korea, and can cause the severe infections known to be associated with this organism.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Bacterial Proteins
/
Bacterial Toxins
/
Polymerase Chain Reaction
/
Methicillin Resistance
/
Bacteremia
/
Exotoxins
/
Korea
/
Leukocidins
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2007
Document type:
Article