Decreased DBC1 Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer
Korean Journal of Urology
; : 631-637, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-145443
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. MATERIALS ANDMETHODS:
The expression of DBC1 was determined by real-time polymerase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model.RESULTS:
DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05).CONCLUSIONS:
The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Urinary Bladder
/
Urinary Bladder Neoplasms
/
Chromosomes, Human, Pair 9
/
Genes, Tumor Suppressor
/
Loss of Heterozygosity
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Kaplan-Meier Estimate
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Real-Time Polymerase Chain Reaction
/
Mucous Membrane
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2013
Document type:
Article