Polymorphism of Matrix Metalloproteinase-3 Promoter Gene as a Risk Factor for Coronary Artery Lesions in Kawasaki Disease
Journal of Korean Medical Science
; : 607-611, 2005.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-147618
Responsible library:
WPRO
ABSTRACT
Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be significantly higher than other diseases. Several studies have demonstrated that MMP-3 5A/6A polymorphism and MMP-9 C-1562T polymorphism modify each transcriptional activity in allele specific manner. We hypothesized that these polymorphisms may play a role as a risk factor for development of coronary artery lesions (CAL) in KD. Eighty-three patients, diagnosed with KD in Cheju National University Hospital from January 2000 to February 2004, were divided into two groups according to the presence of CAL. Genotyping of MMP-3 and MMP-9 gene polymorphisms were determined by restriction fragment length polymorphism. With regard to MMP-3 gene polymorphism, the KD with CAL group had a higher frequency of 6A/6A genotype than control group (p=0.0127) and the KD without CAL group (p=0.0036). However, no significant differences in the allele and genotype distributions of the MMP-9 polymorphism were observed. These findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for CAL formation in KD.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Coronary Artery Disease
/
Risk Factors
/
Promoter Regions, Genetic
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Matrix Metalloproteinase 3
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Matrix Metalloproteinase 9
/
Alleles
/
Gene Frequency
/
Genotype
/
Mucocutaneous Lymph Node Syndrome
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
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Female
/
Humans
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Infant
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2005
Document type:
Article