Two Cases of Metformin-Induced Lactic Acidosis Successfully Treated by Hemodialysis / 대한내과학회지
Korean Journal of Medicine
; : 473-476, 2011.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-152855
Responsible library:
WPRO
ABSTRACT
Metformin-induced lactic acidosis is a rare life-threatening complication associated with metformin treatment and has a high mortality rate. Here, two cases of metformin-induced lactic acidosis are reported. A 22-year-old woman was admitted to our hospital with a metformin overdose (25 g) and lactic acidosis. Hemodialysis was initiated to correct the acidemia, and the patient showed full recovery. Her serum creatinine level returned to normal. A 50-year-old man presented with a 5-day history of muscle weakness. His medical history included diabetes mellitus for 6 years treated with metformin at 3,000 mg/day and hypertension. An arterial blood sample showed metabolic acidosis, with a venous lactate level of 31.1 mg/dL. The patient recovered fully after treatment with bicarbonate dialysis. These cases illustrate that the presence of clinical conditions such as renal failure increase the risk of metformin-induced lactic acidosis. Prompt recognition of lactic acidosis and early treatment with bicarbonate dialysis can result in a successful clinical outcome.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Acidosis
/
Acidosis, Lactic
/
Renal Dialysis
/
Muscle Weakness
/
Lactic Acid
/
Creatinine
/
Diabetes Mellitus
/
Dialysis
/
Renal Insufficiency
/
Hypertension
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Document type:
Article