A case of acetaminophen induced anaphylaxis without aspirin sensitivity / 대한내과학회지
Korean Journal of Medicine
; : S926-S930, 2003.
Article
in Ko
| WPRIM
| ID: wpr-153479
Responsible library:
WPRO
ABSTRACT
Acetaminophen is a world-wide used analgesic and anti-pyretic drug with less anti-in-flammatory effect, available without prescription in most countries. Allergic-like reactions to this drug, including urticaria, angioedema, and anaphylactic reactions have only rarely been reported. This report describes a systemic reaction to acetaminophen documented by oral provocation test in a 30-year-old female patient with a history of anaphylaxis associated with acetaminophen use, in a subject who tolerated aspirin. After an oral challenge with 108.3 mg of acetaminophen, the subject had itching sensation of tongue. With a dose of 162.5 mg (cumulative dose 270.8 mg) acetaminophen, systemic urticaria and rash developed. Also, hand and facial angioedema and chest tightness were noted. Significant change of FEV1 was not noted. But, this patient has bronchial hyperresponsiveness. A rare acute hypersensitivity reaction to acetaminophen without aspirin sensitivity is described in this study. The results of study suggest an other mechanism rather than inhibition of cyclooxygenase as responsible.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pruritus
/
Sensation
/
Thorax
/
Tongue
/
Urticaria
/
Aspirin
/
Prostaglandin-Endoperoxide Synthases
/
Drug Hypersensitivity
/
Exanthema
/
Prescriptions
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
Ko
Journal:
Korean Journal of Medicine
Year:
2003
Document type:
Article