Human Umbilical Cord Blood CD34-Positive Cells as Predictors of the Incidence and Short-Term Outcome of Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot Study
Journal of Clinical Neurology
; : 84-90, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-154742
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neurological handicap in developing countries. Human umbilical cord blood (hUCB) CD34-positive (CD34⁺) stem cells exhibit the potential for neural repair. We tested the hypothesis that hUCB CD34⁺ stem cells and other cell types [leukocytes and nucleated red blood cells (NRBCs)] that are up-regulated during the acute stage of perinatal asphyxia (PA) could play a role in the early prediction of the occurrence, severity, and mortality of HIE.METHODS:
This case-control pilot study investigated consecutive neonates exposed to PA. The hUCB CD34⁺ cell count in mononuclear layers was assayed using a flow cytometer. Twenty full-term neonates with PA and 25 healthy neonates were enrolled in the study.RESULTS:
The absolute CD34⁺ cell count (p=0.02) and the relative CD34⁺ cell count (CD34+%) (p<0.001) in hUCB were higher in the HIE patients (n=20) than the healthy controls. The hUCB absolute CD34⁺ cell count (p=0.04), CD34⁺% (p<0.01), and Hobel risk scores (p=0.04) were higher in patients with moderate-to-severe HIE (n=9) than in those with mild HIE (n=11). The absolute CD34⁺ cell count was strongly correlated with CD34⁺% (p<0.001), Hobel risk score (p=0.04), total leukocyte count (TLC) (p<0.001), and NRBC count (p=0.01). CD34+% was correlated with TLC (p=0.02).CONCLUSIONS:
hUCB CD34⁺ cells can be used to predict the occurrence, severity, and mortality of neonatal HIE after PA.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Cardiovascular Disease
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Cerebrovascular Disease
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Neonatal Healthcare
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Noncommunicable Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Asphyxia
/
Stem Cells
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Umbilical Cord
/
Case-Control Studies
/
Cell Count
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Pilot Projects
/
Incidence
/
Mortality
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Hypoxia-Ischemia, Brain
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Developing Countries
Type of study:
Incidence study
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Observational study
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Prognostic study
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Risk factors
Aspects:
Social determinants of health
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2017
Document type:
Article