PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis
Gut and Liver
; : 456-463, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-155136
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients.METHODS:
We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software.RESULTS:
The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG OR, 2.29; 95% CI, 1.57 to 3.35; pG) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phospholipases
/
Fibrosis
/
Odds Ratio
/
Publication Bias
/
Hepatitis C, Chronic
/
Consensus
/
Asian People
/
Fatty Liver
/
Hepatitis, Chronic
/
Liver Cirrhosis
Type of study:
Etiology study
/
Practice guideline
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2016
Document type:
Article