Limitations of 99mTc-DMSA scan in diagnosing acute pyelonephritis in children / 소아과
Korean Journal of Pediatrics
; : 408-413, 2010.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-155214
Responsible library:
WPRO
ABSTRACT
PURPOSE:
We aimed to prove the relative limitation of 99mTc-DMSA scintigraphy (DMSA) compared to computed tomography (CT) in diagnosing acute pyelonephritis (APN) in children.METHODS:
Since September 2006, after a 64-channel CT was imported, 10 DMSA false-negative patients have been identified these patients underwent a CT scan for acute abdomen or acute febrile symptoms and were diagnosed as having APN; however, their DMSA scans were clear. We focused on these 10 DMSA false-negative patients and analyzed their clinical findings and CT results. We used Philips Brilliance Power 64-channel CT scanner for the CT scan and Siemens Orbitor Nuclear Camera 60 Hz for the DMSA scan.RESULTS:
The 10 DMSA false-negative patients were mostly males (80%) and infants (80%). They had fever for a mean of 1.1-day duration before admission and showed increase in acute reactants leukocyte, erythrocyte sedimentation rate, and C-reactive protein. The CT findings of renal lesions were focal in 6 (60%) cases and diffuse in 4 (40%) cases, and most of the lesions were unilateral in 80% of patients. CT proved that 22 renal lesions were neglected by DMSA. Differential renal function test by DMSA was also of no use in the evaluation of renal lesions.CONCLUSION:
In this study, DMSA scan showed limitation in finding renal cortical lesions of CT-proven APN patients. DMSA false-negative results seem to occur at early-phase disease of infantile age, but more prospective studies are needed to determine the reasons and their prevalence.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Pyelonephritis
/
Blood Sedimentation
/
C-Reactive Protein
/
Gamma Cameras
/
Prevalence
/
Succimer
/
Technetium Tc 99m Dimercaptosuccinic Acid
/
Fever
/
Abdomen, Acute
/
Leukocytes
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
Limits:
Child
/
Humans
/
Infant
/
Male
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2010
Document type:
Article