Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy
Radiation Oncology Journal
; : 48-54, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-156651
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study aimed to assess the effects of body mass index (BMI) on survival in cervical cancer patients who had undergone surgery and radiotherapy (RT). MATERIALS ANDMETHODS:
We retrospectively reviewed the medical records of 70 cervical cancer patients who underwent surgery and RT from 2007 to 2012. Among them, 40 patients (57.1%) had pelvic lymph node metastases at the time of diagnosis. Sixty-seven patients (95.7%) had received chemotherapy. All patients had undergone surgery and postoperative RT. Median BMI of patients was 22.8 kg/m² (range, 17.7 to 35.9 kg/m²).RESULTS:
The median duration of follow-up was 52.3 months (range, 16 to 107 months). Twenty-four patients (34.3%) showed recurrence. Local failure, regional lymph nodal failure, and distant failure occurred in 4 (5.7%), 6 (8.6%), and 17 (24.3%) patients, respectively. The 5-year actuarial pelvic control rate was 83.4%. The 5-year cancer-specific survival (CSS) and disease-free survival (DFS) rates were 85.1% and 65.0%, respectively. The presence of pelvic lymph node metastases (n = 30) and being overweight or obese (n = 34, BMI ≥ 23 kg/m²) were poor prognostic factors for CSS (p = 0.003 and p = 0.045, respectively). Of these, pelvic lymph node metastasis was an independent prognostic factor (p = 0.030) for CSS.CONCLUSION:
Overweight or obese cervical cancer patients showed poorer survival outcomes than normal weight or underweight patients. Weight control seems to be important in cervical cancer patients to improve clinical outcomes.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cervical Cancer
/
Endocrine System Diseases
/
Obesity
Database:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Recurrence
/
Thinness
/
Body Weight
/
Body Mass Index
/
Uterine Cervical Neoplasms
/
Medical Records
/
Retrospective Studies
/
Follow-Up Studies
/
Disease-Free Survival
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2017
Document type:
Article