Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome
Journal of Korean Medical Science
; : 883-889, 2012.
Article
in En
| WPRIM
| ID: wpr-159027
Responsible library:
WPRO
ABSTRACT
The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Prognosis
/
Recurrence
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Thyroidectomy
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Thyroid Neoplasms
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Carcinoma
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Carcinoma, Papillary
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Odds Ratio
/
Sex Factors
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Survival Rate
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Predictive Value of Tests
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
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Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2012
Document type:
Article