Biochemical Markers as Predictors of In-Hospital Mortality in Patients with Severe Trauma: A Retrospective Cohort Study / 대한중환자의학회지
Korean Journal of Critical Care Medicine
; : 240-246, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-159866
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Initial evaluation of injury severity in trauma patients is an important and challenging task. We aimed to assess whether easily measurable biochemical parameters (hemoglobin, pH, and prothrombin time/international normalized ratio [PT/INR]) can predict in-hospital mortality in patients with severe trauma.METHODS:
This retrospective study involved review of the medical records of 315 patients with severe trauma and an injury severity score >15 who were managed at Gyeongsang National University Hospital between January 2005 and December 2015. We extracted the following data in-hospital mortality, injury severity score, and initial hemoglobin level, pH, and PT/INR. The predictive values of these variables were compared using receiver operation characteristic curves.RESULTS:
Of the 315 patients, 72 (22.9%) died. The in-hospital mortality rates of patients with hemoglobin levels <8.4 g/dl and ≥8.4 g/dl were 49.8% and 9.9%, respectively (P < 0.001). At a cutoff hemoglobin level of 8.4 g/dl, the sensitivity and specificity values for mortality were 81.9% and 86.4%, respectively. At a pH cutoff of 7.25, the sensitivity and specificity values for mortality were 66.7% and 77.8%, respectively; 66.7% of patients with a pH <7.25 died versus 22.2% with a pH ≥7.25 (P < 0.001). The in-hospital mortality rates for patients with PT/INR values ≥1.4 and <1.4 were 37.5% and 16%, respectively (P < 0.001; sensitivity, 37.5%; specificity, 84%).CONCLUSIONS:
Using the suggested cutoff values, hemoglobin level, pH, and PT/INR can simply and easily be used to predict in-hospital mortality in patients with severe trauma.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Endocrine System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Acidosis
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Prothrombin
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Biomarkers
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Injury Severity Score
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Medical Records
/
Retrospective Studies
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Cohort Studies
/
Mortality
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Sensitivity and Specificity
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Hospital Mortality
Type of study:
Diagnostic study
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Etiology study
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Incidence study
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Observational study
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Prognostic study
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Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Critical Care Medicine
Year:
2017
Document type:
Article