Analysis of lysosomal membrane proteins exposed to melanin in HeLa cells
Environmental Health and Toxicology
; : e2016009-2016.
Article
in En
| WPRIM
| ID: wpr-162228
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
There have been developed to use targeting ability for antimicrobial, anticancerous, gene therapy and cosmetics through analysis of various membrane proteins isolated from cell organelles.METHODS:
It was examined about the lysosomal membrane protein extracted from lysosome isolated from HeLa cell treated by 100 ppm melanin for 24 hours in order to find associated with targeting ability to melanin using by 2-dimensional electrophoresis.RESULTS:
The result showed 14 up-regulated (1.5-fold) and 13 down-regulated (2.0-fold) spots in relation to melanin exposure.CONCLUSIONS:
It has been found that lysosomal membrane proteins are associated with melanin to decolorize and quantity through cellular activation of lysosome.Key words
Full text:
1
Database:
WPRIM
Main subject:
HeLa Cells
/
Genetic Therapy
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Organelles
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Electrophoresis
/
Lysosomal Membrane Proteins
/
Lysosomes
/
Melanins
/
Membrane Proteins
Limits:
Humans
Language:
En
Journal:
Environmental Health and Toxicology
Year:
2016
Document type:
Article