Elevated plasma fibrinogen levels and prognosis of epithelial ovarian cancer: a cohort study and meta-analysis / 부인종양
Journal of Gynecologic Oncology
; : e36-2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-163711
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To evaluate the effect of elevated plasma fibrinogen levels on the prognosis of epithelial ovarian cancer (EOC).METHODS:
We reviewed the data of 217 patients with advanced-stage EOC between 2000 and 2012, and investigated the prognostic role of elevated plasma fibrinogen levels compared with serum CA-125 levels, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). For further evaluation, we performed a meta-analysis using 5 cohort studies published to July 2015, including our cohort study after a literature review.RESULTS:
Among the four biomarkers, only plasma fibrinogen levels >485.2 mg/dL were correlated with impaired progression-free survival (PFS) and overall survival (OS) (median, 13.9 vs. 20.3 months and 42.2 vs. 55.4 months; p<0.010). Elevated plasma fibrinogen levels were an independent factor for poor PFS with marginal significance and OS (adjusted hazard ratios [HRs]=1.389 and 1.581; 95% confidence intervals [CIs]=0.979–1.972 and 1.032–2.423, respectively). Furthermore, crude and subgroup meta-analyses demonstrated that elevated plasma fibrinogen levels were associated with impaired PFS and OS in patients with all stage EOC.CONCLUSION:
Elevated plasma fibrinogen levels be more important for predicting survival than serum CA-125 levels, NLR and PLR in patients with EOC, in particular, advanced-stage disease. Moreover, it may be related to poor prognosis of EOC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Plasma
/
Prognosis
/
Blood Platelets
/
Fibrinogen
/
Lymphocytes
/
Biomarkers
/
Cohort Studies
/
Disease-Free Survival
/
Neutrophils
Type of study:
Etiology study
/
Incidence study
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Observational study
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Prognostic study
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2017
Document type:
Article