High pretransplant HBV level predicts HBV reactivation after kidney transplantation in HBV infected recipients
Annals of Surgical Treatment and Research
; : 256-263, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-163741
Responsible library:
WPRO
ABSTRACT
PURPOSE:
HBsAg-positive kidney recipients are at increased risk for mortality and graft failure. The aims of this study were to identify the outcomes of HBsAg-positive recipients who received preemptive antiviral agents after successful kidney transplantation and to analyze risk factors for HBV reactivation.METHODS:
We retrospectively reviewed the medical records of 944 patients performed kidney transplantation between 1999 and 2010.RESULTS:
HBsAg-negative recipients were 902 patients and HBsAg-positive recipients, 42. Among HBsAg-positive recipients, HBV reactivation was detected in 7 patients and well controlled by switch or combination therapy. Graft failure developed in only one patient due to chronic rejection regardless of HBV reactivation but no deaths occurred. All patients were alive at the end of follow-up and none developed end-stage liver disease or hepatocellular carcinoma. There was statistically significant difference in graft survival between HBsAg-positive recipients and HBsAg-negative. Multivariate analysis identified increased HBV DNA levels (>5 x 10(4) IU/mL) in the HBsAg-positive kidney transplant recipients as a risk factor for HBV reactivation (P = 0.007).CONCLUSION:
Effective viral suppression with antiviral agents in HBsAg-positive renal transplant recipients improves patient outcome and allograft survival. Antiviral therapy may be especially beneficial in patients with high HBV DNA levels prior to transplantation.
Full text:
Available
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Hepatitis
/
Digestive System Diseases
/
Kidney, Renal Pelvis and Ureter Cancer
/
Liver Cancer
Database:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Transplantation
/
DNA
/
Hepatitis B virus
/
Medical Records
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
/
Mortality
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2014
Document type:
Article