Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of enteroviral meningitis / 소아과
Korean Journal of Pediatrics
; : 446-450, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-163867
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Meningitis is among the most common infections affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the infection and patients are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of enteroviral meningitis in children and evaluate the diagnostic efficacy of reverse transcriptase-polymerase chain reaction (RT-PCR) for early detection of an enterovirus.METHODS:
We analyzed the medical records of children admitted to Korea University Medical Center and diagnosed with meningitis on the basis of cerebrospinal fluid (CSF) analysis and RT-PCR from CSF and other samples from January 2010 to August 2013.RESULTS:
A total of 333 patients were enrolled and classified into four groups based on diagnosis enteroviral meningitis (n=110), bacterial meningitis (n=23), other viral meningitis (n=36), and unknown etiology (n=164). Patients with bacterial meningitis were younger than those in the other groups (P<0.001). Pleocytosis in CSF was similar across all groups. Of patients in the enteroviral meningitis group, 92.7% were diagnosed based on RT-PCR findings. Mean length of hospital stay for patients with enteroviral meningitis was 6.08 days, which was significantly shorter than that for patients with meningitis of bacterial etiology (19.73 days, P<0.001).CONCLUSION:
Diagnosis of enteroviral meningitis before viral culture results are available is possible using RT-PCR. Accurate diagnosis reduces the length of hospital stay and helps to avoid unnecessary empiric antibiotic treatment.
Full text:
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Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.3: End transmission of communicable diseases
/
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Neglected Diseases
/
Zoonoses
/
Meningitis
/
Infections
Database:
WPRIM (Western Pacific)
Main subject:
Central Nervous System
/
Cerebrospinal Fluid
/
Medical Records
/
Meningitis, Bacterial
/
Enterovirus
/
Reverse Transcriptase Polymerase Chain Reaction
/
Early Diagnosis
/
Diagnosis
/
Academic Medical Centers
/
Korea
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2015
Document type:
Article