Small Bowel Infarction by Mesenteric Venous Thrombosis due to Methylenetetrahydrofolate Reductase Gene Mutation
Soonchunhyang Medical Science
; : 112-115, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-165839
Responsible library:
WPRO
ABSTRACT
Acute mesenteric venous thrombosis (MVT) is an uncommon form of intestinal ischemia with high mortality and usually occurs in the setting of preexisting comorbidities including thrombophilia and abdominal inflammatory conditions. Hyperhomocysteinemia has been known to be a risk factor for thromboembolism, often located on an unusual site. Considering that homocysteine metabolism is determined genetically to a high degree, a mutant of methylenetetrahydrofolate reductase (MTHFR) C677T causes hyperhomocysteinemia, leading to thrombophilia. Until now, there have been few reports of MVT associated with MTHFR gene mutation. We, herein, report a case of small bowel infarction associated with MVT by MTHFR gene mutation in an adult without any other risk factors of thrombophilia.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Endocrine System Diseases
/
Malnutrition and Nutritional Deficiencies
/
Venous Thromboembolic Disease
Database:
WPRIM (Western Pacific)
Main subject:
Thromboembolism
/
Thrombosis
/
Comorbidity
/
Risk Factors
/
Mortality
/
Thrombophilia
/
Venous Thrombosis
/
Hyperhomocysteinemia
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Homocysteine
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Soonchunhyang Medical Science
Year:
2014
Document type:
Article