Therapy-related myeloid neoplasms in children and adolescents
Blood Research
; : 242-248, 2016.
Article
in En
| WPRIM
| ID: wpr-167172
Responsible library:
WPRO
ABSTRACT
BACKGROUND: This retrospective study aimed to characterize and analyze the outcome of therapy-related myeloid neoplasms (t-MNs) in children and adolescents. METHODS: The medical records of 16 patients under 21 years of age at the time of t-MN diagnosis were reviewed. RESULTS: The median patient age was 11.5 years (range, 1.6–20.4 yr). Twelve patients had therapy-related acute myeloid leukemia, 3 patients had myelodysplastic syndrome, and 1 patient had chronic myelomonocytic leukemia. The median latency period was 29 months (range, 11–68 mo). Fourteen patients had cytogenetic aberrations, 8 of whom had an 11q23 abnormality. Of the 13 patients treated with curative intent, 12 patients received myeloid-type induction therapy that led to complete remission (CR) in 8 patients. Nine patients underwent allogeneic transplantation; 4 patients did not undergo transplantation due to chemotherapy-related toxic death (N=3) or parental refusal (N=1). The 5-year overall survival and event-free survival of the 13 patients treated with a curative intent were 46.2% and 30.8%, respectively. For the 9 patients who underwent allogeneic transplantation, the 5-year event-free survival was 66.7%. CONCLUSION: A significant proportion of young patients with t-MNs can experience long-term survival, and allogeneic transplantation plays a key role for attaining cure in these patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Parents
/
Transplantation, Homologous
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Myelodysplastic Syndromes
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Leukemia, Myelomonocytic, Chronic
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Leukemia, Myeloid, Acute
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Medical Records
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Retrospective Studies
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Chromosome Aberrations
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Disease-Free Survival
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Diagnosis
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adolescent
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Child
/
Humans
Language:
En
Journal:
Blood Research
Year:
2016
Document type:
Article