Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis / 체질인류학회지
Korean Journal of Physical Anthropology
; : 71-79, 2013.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-167685
Responsible library:
WPRO
ABSTRACT
Trimellitic anhydride (TMA) is widely used industrially to make epoxy and alkyd resins, plasticizers and surfactants. The purpose of this study was to investigate whether contact dermatitis is induced by repeated TMA challenge and the role of interleukin (IL)-10 in the TMA-induced contact dermatitis. The repetition of the challenge enlarged the extent of an early and a late phase of contact dermatitis in IL-10(+/+) and IL-10(-/-) mice. In the late phase of TMA-induced contact dermatitis, the peak of ear swelling responses by single challenge showed at 12 h after challenge, but the peak was observed at 8 h after repeated challenge. In the IL-10(-/-) mice, the repetition of the TMA challenges enlarged the extent of the contact dermatitis, but less than those in IL-10(+/+) mice. These results indicate that mice sensitized by TMA could possibly offer a useful model to study the mechanism of contact dermatitis, and IL-10 may act as potential modulators in the TMA-induced contact dermatitis. IL-10 may provide therapeutic tools for the treatment of TMA-induced contact dermatitis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phthalic Anhydrides
/
Plasticizers
/
Plastics
/
Interleukins
/
Interleukin-10
/
Dermatitis, Contact
/
Ear
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Physical Anthropology
Year:
2013
Document type:
Article