A lack of association between vitamin D-binding protein and 25-hydroxyvitamin D concentrations in pediatric type 1 diabetes without microalbuminuria
Annals of Pediatric Endocrinology & Metabolism
; : 247-252, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-169580
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation. We aimed to evaluate the possible increased urinary loss of VDBP, a correlation between VDBP and circulating 25(OH)D level, and risk factors influencing low vitamin D level in pediatric type 1 diabetes patients without microalbuminuria.METHODS:
This is a cross-sectional study of subjects who visited Seoul National University Children’s Hospital between January and March 2013. Forty-two type 1 diabetes patients and 29 healthy controls were included. Biochemical parameters including serum and urine VDBP concentrations were analyzed.RESULTS:
There was no significant difference in the frequency of vitamin D deficiency or serum 25(OH)D level between the 2 groups. The serum and urine VDBP concentrations did not show any difference between the 2 groups. Serum 25(OH) D level did not correlate with serum or urine VDBP. Multivariate regression analysis revealed that daylight outdoor hours (β=2.948, P=0.003) and vitamin D intake (β=2.865, P=0.003) affected the 25(OH)D level; the presence of type 1 diabetes or urinary VDBP excretion was not significant.CONCLUSIONS:
In pediatric type 1 diabetes patients, urinary VDBP excretion did not contribute to low serum 25(OH)D level in the setting of normoalbuminuria. The factors associated with 25(OH)D level during winter periods were daylight outdoor hours and vitamin D intake. Further studies including both micro- and macroalbuminuria patients with type 1 diabetes are warranted.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vitamin D
/
Vitamin D-Binding Protein
/
Vitamin D Deficiency
/
Vitamins
/
Ergocalciferols
/
Cross-Sectional Studies
/
Risk Factors
/
Diabetes Mellitus, Type 1
/
Albuminuria
/
Seoul
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2017
Document type:
Article