Impact of Caveolin-1 Expression on the Prognosis of Transitional Cell Carcinoma of the Upper Urinary Tract
Journal of Korean Medical Science
; : 296-301, 2008.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-173550
Responsible library:
WPRO
ABSTRACT
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Carcinoma, Transitional Cell
/
Gene Expression Regulation, Neoplastic
/
Urologic Neoplasms
/
Disease-Free Survival
/
Disease Progression
/
Gene Expression Profiling
/
Caveolin 1
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2008
Document type:
Article