Immunohistochemical Study of Bcl-2 Oncoprotein Expression in Childhood Non-Hodgkin's Lymphoma
Journal of the Korean Pediatric Society
; : 1265-1274, 1997.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-174200
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aim of the present study was to assess the clinicopatholgical significance of Bcl-2 oncoprotein expression in childhood non-Hodgkin's lymphoma (NHL).METHODS:
We have assessed 16 cases of childhood NHL during last 6 years from 1990 to 1995. Bcl-2 oncoprotein expression has been semiquantitatively analyzed in paraffin sections from 16 cases of childhood NHL with 39 control cases of adult NHL. The expression of Bcl-2 oncoprotein was correlated with histologic grade, immunophenotype, proliferative activity as measured by immunostain of Ki-67 antigen, clinical stage, and survival rate (event free survival rate, EFS).RESULTS:
1) Bcl-2 oncoprotein expression significantly decreased according to increase of histological grade (P0.05). 5) EFS of patients was significantly correlated with Bcl-2 oncoprotein expression, that is, reduced EFS was demonstrated in the patients with low Bcl-2 oncoprotein expression (P<0.05).CONCLUSIONS:
Thus Bcl-2 oncoprotein, as demonstrated immunohistochemically in routinely paraffin embedded tissue, can be restrictively used in prediction of prognosis and grade of childhood NHL, in aggrement with the role of Bcl-2 oncoprotein in blocking of apoptosis and indirect contribution to increase of cellular proliferative activity of NHL.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Lymphomas and Multiple Myeloma
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Noncommunicable Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Paraffin
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Prognosis
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Lymphoma, Non-Hodgkin
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B-Lymphocytes
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T-Lymphocytes
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Survival Rate
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Apoptosis
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Ki-67 Antigen
Type of study:
Prognostic study
Limits:
Adult
/
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1997
Document type:
Article