Two Cases of Rhinocerebral Mucormycosis in Diabetic Patients

ABSTRACT

Rhinocerebral mucormycosis is a rare fungal infection that involves the paranasal sinus and orbits and usually presents as acute invasive fungal sinusitis. It progresses rapidly, is often fatal, and occurs most commonly in patients with uncontrolled diabetes. If the condition is not treated, the fungal infection may disseminate into the brain and cause death within a week. We encountered two cases of rhinocerebral mucormycosis confirmed with histophathological examination. The cases were treated successfully with surgical debridement, a systematic application of amphotericin B, and irrigation and soakage with amphotericin B.