Effect of Finasteride on Free/Total Serum PSA Ratio in Patients with Benign Prostate Hyperplasia / 대한비뇨기과학회지
Korean Journal of Urology
; : 1301-1304, 1999.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-17624
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Finasteride, a 5-alpha reductase inhibitor, has recently been used as a treatment for men with benign prostate hyperplasia(BPH). This study was undertaken to determine whether free-to-total(f/t) PSA ratio changed during the finasteride therapy in patient with BPH and whether it is possible to use this new discriminant ratio after prolonged treatment with finasteride. MATERIALS ANDMETHODS:
The study comprised 31 men (mean age 66 years) with finasteride therapy for BPH. Blood samples were taken before and after 3-13months of therapy with finasteride and f/t PSA ratio is determined using radioimmunometric assay.RESULTS:
Although the mean t-PSA, f-PSA are significantly decreased after the treatment with finasteride, f/t PSA ratio remained unchanged. The duration of treatment and the level of initial t-PSA did not affect the f/t PSA ratio.CONCLUSIONS:
The f/t PSA ratio is unchanged among the patients with finasteride therapy for BPH.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Finasteride
/
Hyperplasia
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1999
Document type:
Article