The Clinical Course and Outcomes of Post-Transplantation Diabetes Mellitus after Heart Transplantation
Journal of Korean Medical Science
; : 1460-1467, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-178284
Responsible library:
WPRO
ABSTRACT
The aim of this study was to describe in more detail the predisposition, natural course, and clinical impact of post-transplantation diabetes mellitus (PTDM) after heart transplantation (HT). The characteristics and clinical outcomes of 54 patients with PTDM were compared with those of 140 patients without PTDM. The mean age of PTDM patients was significantly higher than controls (48.9 +/- 9.3 vs 38.6 +/- 13.3 yr, respectively, P = 0.001), and ischemic heart disease was a more common indication of HT (20.4% [11/54] vs 7.1% [10/140], respectively, P = 0.008). In multivariate analysis, only recipient age (odds ratio, 1.80; 95% confidence interval, 1.35-2.40; P = 0.001) was associated with PTDM development. In 18 patients (33%), PTDM was reversed during the follow-up period, and the reversal of PTDM was critically dependent on the time taken to develop PTDM (1.9 +/- 1.0 months in the reversed group vs 14.5 +/- 25.3 months in the maintained group, P = 0.005). The 5-yr incidence of late infection (after 6 months) was higher in the PTDM group than in the control group (30.4% +/- 7.1% vs 15.4% +/- 3.3%, respectively, P = 0.031). However, the 5-yr overall survival rate was not different (92.9% +/- 4.1% vs 85.8% +/- 3.2%, respectively, P = 0.220). In conclusion, PTDM after HT is reversible in one-third of patients and is not a critical factor in patient survival after HT.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Transplantation, Homologous
/
Glycated Hemoglobin
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Registries
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Incidence
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Survival Rate
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Cohort Studies
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Follow-Up Studies
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Heart Transplantation
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Treatment Outcome
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Diabetes Mellitus
Type of study:
Etiology study
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Incidence study
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Observational study
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Prognostic study
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Risk factors
Limits:
Adult
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Female
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Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Document type:
Article