Synthesis and antifungal and antibacterial activities of P-phenylen-Dithioure derivatives

ABSTRACT

p-phenylendiamin was obtained by the nitration, hydrolysis and reduction of acetanilide. The reaction between p-phenylendiamin and CS2 in ammoniac solution produced p-phenylen bis-dithiocarbamat, which was performed oxidatively with lead nitrat and was converted into p-phenylendiisothiocyanat. -Condensation of 1,4-phenylendiisothiocyanat with amine compounds (p-aminosalicylic acide, p-aminobenzoic acide and their derivatives to get 10 dithiourea dervatives. -The purity of products were controlled by thin layer chromatography. The structures of them were determined by elemental analysis and IR spectroscopy. -The study indicated that all of them have strong antifunggal properpies but weak effect on bacteria