Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 205-211, 2002.
Article
in Ko
| WPRIM
| ID: wpr-18019
Responsible library:
WPRO
ABSTRACT
PURPOSE: To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model. RESULTS: No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8). CONCLUSION: Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
Breast
/
Breast Neoplasms
/
Alcohol Drinking
/
Case-Control Studies
/
Logistic Models
/
Polymerase Chain Reaction
/
Risk Factors
/
Alleles
/
Genotype
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Cancer Research and Treatment
Year:
2002
Document type:
Article