Regulation of Innate Immunity via MHC Class II-mediated Signaling; Non-classical Role of MHC Class II in Innate Immunity
Journal of Bacteriology and Virology
; : 205-207, 2011.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-181167
Responsible library:
WPRO
ABSTRACT
MHC class II has long been known to play a classical role in antigen presentation and to act as a signal transducer capable of inducing the adaptive immunity needed to produce pathogen specific antibodies. However, it has recently been revealed that MHC class II can also promote the activation of Toll-like receptor mediated signaling by functioning as an adapter. This means that in addition to its classical function of adaptive immunity, MHC class II also plays an intriguing role in the mechanisms that regulate innate immunity. That being the case, queries inevitably arise regarding the fact that many pathogens have tried to control the induction of MHC class II so as to escape the host immune response. Liu et al (Nat Immunol 2011;12416-424) demonstrated that intracellular MHC class II interacted with Btk, and that this activated Btk promoted TLR signaling via Myd88 and TRIF. The results of this study provide insight regarding the possibility of a novel role for MHC class II, which was heretofore regarded solely as a classical molecule involved in adaptive immune responses, as a regulator of innate immune responses.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Transducers
/
United Nations
/
Antigen Presentation
/
Toll-Like Receptors
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Adaptive Immunity
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Immunity, Innate
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Antibodies
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2011
Document type:
Article