NF-kappaB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
The Korean Journal of Parasitology
; : 291-294, 2011.
Article
in En
| WPRIM
| ID: wpr-182102
Responsible library:
WPRO
ABSTRACT
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1x10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-kappaB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with ikappaB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-kappaB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Phosphorylation
/
Trichomonas vaginalis
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Interleukin-8
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NF-kappa B
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Cyclic AMP Response Element-Binding Protein
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Human Experimentation
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Neutrophils
Limits:
Humans
/
Male
Language:
En
Journal:
The Korean Journal of Parasitology
Year:
2011
Document type:
Article