The relationship between pregnancy rate and suppression of luteinizing hormone in IVF-ET program / 대한산부인과학회지

ABSTRACT

OBJECTIVE: To investigate the effect of profound LH suppression in the late follicular phase during controlled ovarian hyperstimulation (COH) on pregnancy rate. METHODS: Data were collected by retrospective analysis. A total of 172 cycles of oocytes retrieval for IVF after COH with GnRH agonist-down regulation and hMG/FSH were included from January 1999 to July 2002. Serum LH, FSH, estradiol and progesterone concentrations were measured on the day 3 of the preceding cycle and LH concentration was measured on the day of hCG administration. Based on LH concentrations (mIU/mL) on the day of hCG administration, cycles are classfied to two groups (group 1 LH>0.7 mIU/mL, group 2 LHRESULTS: There were no significant differences between the two groups in the demographic characteristics, baseline hormone levels, number of eggs retrieved and fertilization rate. Pregnancy rate in the group 1 is higher than that of group 2.

CONCLUSION:

Patients with profound suppression of LH on the day of hCG administration were found to have worse reproductive outcome.