Effects of Repetitive Transcranial Magnetic Stimulation on Behavioral Recovery during Early Stage of Traumatic Brain Injury in Rats
Journal of Korean Medical Science
; : 1496-1502, 2015.
Article
in En
| WPRIM
| ID: wpr-184030
Responsible library:
WPRO
ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) is a promising technique that modulates neural networks. However, there were few studies evaluating the effects of rTMS in traumatic brain injury (TBI). Herein, we assessed the effectiveness of rTMS on behavioral recovery and metabolic changes using brain magnetic resonance spectroscopy (MRS) in a rat model of TBI. We also evaluated the safety of rTMS by measuring brain swelling with brain magnetic resonance imaging (MRI). Twenty male Sprague-Dawley rats underwent lateral fluid percussion and were randomly assigned to the sham (n=10) or the rTMS (n=10) group. rTMS was applied on the fourth day after TBI and consisted of 10 daily sessions for 2 weeks with 10 Hz frequency (total pulses=3,000). Although the rTMS group showed an anti-apoptotic effect around the peri-lesional area, functional improvements were not significantly different between the two groups. Additionally, rTMS did not modulate brain metabolites in MRS, nor was there any change of brain lesion or edema after magnetic stimulation. These data suggest that rTMS did not have beneficial effects on motor recovery during early stages of TBI, although an anti-apoptosis was observed in the peri-lesional area.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Behavior, Animal
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Brain
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Brain Injuries
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Magnetic Resonance Imaging
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Treatment Outcome
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Rats, Sprague-Dawley
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Recovery of Function
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Disease Models, Animal
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Transcranial Magnetic Stimulation
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Motor Activity
Limits:
Animals
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2015
Document type:
Article