Infusional 5-Fluorouracil, Leucovorin and Docetaxel in Advanced Gastric Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 123-129, 2003.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-18457
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study was performed to estimate the response rate and toxicity of a combination chemotherapy, which included infusional 5-Fluorouracil, Leucovorin and Docetaxel in the treatment of patients with an advanced gastric carcinoma. MATERIALS ANDMETHODS:
Twenty two advanced gastric cancer patients, with a bidimensionally measurable or an evaluable disease, were enrolled in this study. The patients received a 5-fluorouracil 1, 000 mg/m2 intravenous (IV) 24 hour infusion (Day 1~3), leucovorin 20 mg/m2 (Day 1~3) and docetaxel 75 mg/m2 intravenously (Day 2) every 3 weeks.RESULTS:
The overall response rate was 45.0%. The median duration of response was 10.0 weeks (range 4~24), the median time to response was 8 weeks (range 8~20) the median time to progression was 30.0 weeks (95% CI 16.3~43.2) and the median overall survival duration was 36.0 weeks (95% CI 1.7~70.2). The median cumulative dose of 5-fluorouracil were 316.2 mg/m2/week and docetaxel was 23.9 mg/m2/week. WHO grade III, IV neutropenia, thromocytopenia and anemia occurred in 50.0%, 4.5% and 4.5% of patients, respectively. There were no occurrence of WHO grade III and IV nausea, vomiting, mucositis, conspitation, diarrhea, or neurotoxicity.CONCLUSION:
This chemotherapy regimen, including infusional 5-fluorouracil, leucovorin and docetaxel was an active agent against advanced gastric cancer patients, especially for previous chemotherapy naive patients.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Diarrhea
/
Neglected Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Vomiting
/
Leucovorin
/
Diarrhea
/
Drug Therapy
/
Drug Therapy, Combination
/
Mucositis
/
Fluorouracil
/
Anemia
/
Nausea
Limits:
Humans
Language:
Korean
Journal:
Cancer Research and Treatment
Year:
2003
Document type:
Article