Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
Experimental Neurobiology
; : 262-268, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-184903
Responsible library:
WPRO
ABSTRACT
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like receptors (TLRs) are closely related with inflammatory responses of microglia and astrocytes and these signaling pathways regulate neuroinflammation. Previous reports have identified the anti-inflammatory effects of TSPO ligands, however study of their effects in relation to the TLR signaling was limited. Here, we investigated the effects of five representative TSPO ligands on microglia and astrocytes following activation by various TLR ligands. Our results show that TSPO ligands reduce the pro-inflammatory response elicited by the TLR ligands with more profound effects on microglia than astrocytes.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Brain
/
Astrocytes
/
Microglia
/
Mitochondrial Proteins
/
Toll-Like Receptors
/
Ligands
Language:
English
Journal:
Experimental Neurobiology
Year:
2016
Document type:
Article