Antibody Responses in Hematopoietic Cell Transplantation Recipients after Vaccination Against Haemophilus Influenzae Type b and Streptococcus pneumoniae / 소아감염
Korean Journal of Pediatric Infectious Diseases
; : 81-95, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-188745
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Hematopoietic cell transplantation (HCT) recipients are vulnerable to invasive infection by Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (Sp). This study was performed to evaluate immune responses after Hib and Sp vaccination in Korean pediatric HCT recipients.METHODS:
Patients were prospectively enrolled at Samsung Medical Center during 2009-2011. ELISA tests to detect anti-PRP IgG antibody and antibodies to Sp serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F were performed at the Center for Vaccine Evaluation and Study, Ewha Medical Research Institute.RESULTS:
Ten patients (two allogeneic, eight autologous recipients) with median age 5.4 years (range 2.7-12.2 years) were enrolled. Before Hib vaccination, 60% of patients' anti-PRP IgG titers were below 0.15 microg/mL. After vaccination, 100% of patients' anti-PRP IgG titers increased above 0.15 microg/mL (cut-off value for detection) and 1.0 microg/mL (cut-off value for seroprotection). For pneumococcus, in 2-5 year-old patients, pre-vaccination geometric mean concentrations (GMCs) of IgG for six serotypes (4, 6B, 9V, 14, 18C, and 23F) were below 0.35 microg/mL and at 5 months post-vaccination GMCs of IgG for all seven serotypes increased to above 0.35 microg/mL. In patients older than 5 years, pre-vaccination GMCs of IgG for four serotypes (4, 9V, 14, and 23F) were below 0.35 microg/mL and at 3 months post-vaccination GMCs of IgG for all seven serotypes increased to above 0.35 microg/mL.CONCLUSION:
Most HCT recipients had low or no protective antibodies to Hib and Sp before vaccination, but showed good immune responses to protective levels after vaccination.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Goal 5: Medicines, vaccines and health technologies
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Target 3.3: End transmission of communicable diseases
/
Pneumonia
Database:
WPRIM (Western Pacific)
Main subject:
Streptococcus pneumoniae
/
Immunoglobulin G
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Enzyme-Linked Immunosorbent Assay
/
Prospective Studies
/
Vaccination
/
Cell Transplantation
/
Haemophilus influenzae type b
/
Transplants
/
Academies and Institutes
/
Antibodies
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pediatric Infectious Diseases
Year:
2014
Document type:
Article