Stent Thrombosis after Successful Drug-Eluting Stent Implantation
Korean Circulation Journal
; : 163-171, 2005.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-18993
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Stent thrombosis (ST) after a successful drug-eluting stent (DES) implantation has been reported in around 1% of clinical trials. However, the incidence of ST with a DES in practice is not well known. Here, we evaluated the possible causes of ST encountered in four Korean hospitals. SUBJECTS ANDMETHODS:
Between March 2003 and December 2003, 450 patients were treated using a DES in the four study hospitals. We reviewed the clinical and procedural characteristics of 8 patients that experienced ST after a successful DES implantation.RESULTS:
Eight patients (1.8%), who were administered antiplatelet medication, experienced ST, with a mortality of 50% at the 2 month follow-up. ST occurred within 7 days in all patients, with the exception of one, with an occurrence 37 days after intervention. Initially, all patients were diagnosed as having acute coronary syndrome. Direct PTCA was performed in 3 patients (38%). Severe calcification or a thrombus was noted in 6 (67%) of 9 lesions. In all cases, no GPIIbIIIa inhibitors were used prior to the DES implantation. Incomplete lesion coverage and incomplete stent expansion appeared in 7 (88%) cases.CONCLUSION:
Our study demonstrated that full expansion of the DES and complete lesion coverage must be accomplished, with high pressure inflation or use of cutting balloon preferably under IVUS guidance, for the prevention of ST. Those patients with acute coronary syndrome might warrant intensive antiplatelet therapy, including GPIIbIIIa inhibitors.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Ischemic Heart Disease
Database:
WPRIM (Western Pacific)
Main subject:
Thrombosis
/
Coronary Thrombosis
/
Stents
/
Incidence
/
Follow-Up Studies
/
Mortality
/
Acute Coronary Syndrome
/
Drug-Eluting Stents
/
Inflation, Economic
Type of study:
Practice guideline
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2005
Document type:
Article