Effect of Sub-Minimal Inhibitory Concentration Antibiotics on Morphology of Periodontal Pathogens
International Journal of Oral Biology
; : 115-120, 2014.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-190840
Responsible library:
WPRO
ABSTRACT
Minimal inhibitory concentration (MIC) is the lowest concentration of antibiotics that inhibits the visible growth of a microorganism. It has been reported that sub-MIC of antibiotics may result in morphological alterations along with biochemical and physiological changes in bacteria. The purpose of this study was to examine morphological changes of periodontal pathogens after treatment with sub-MIC antibiotics. Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis were used in this study. The MIC for amoxicillin, doxycycline, metronidazole, penicillin, and tetracycline were determined by broth dilution method. The bacterial morphology was observed with bright field microscope after incubating with sub-MIC antibiotics. The length of A. actinomycetemcomitans and F. nucleatum were increased after incubation with metronidazole; penicillin and amoxicillin. P. gingivalis were increased after incubating with metronidazole and penicillin. However, F. nucleatum showed decreased length after incubation with doxycycline and tetracycline. In this study, we observed that sub-MIC antibiotics can affect the morphology of periodontal pathogens.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Penicillins
/
Tetracycline
/
Bacteria
/
Fusobacterium nucleatum
/
Aggregatibacter actinomycetemcomitans
/
Doxycycline
/
Porphyromonas gingivalis
/
Amoxicillin
/
Metronidazole
/
Anti-Bacterial Agents
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2014
Document type:
Article