Expression of p53, p21, Cycin D1, and Ki-67 in Sinonasal Tumors
Journal of Rhinology
; : 108-114, 2008.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-192080
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
The goal of this study is to investigate alterations of cell-cycle-related molecules, including p53, p21, cyclin D1 and Ki-67, in tumors arising in the sinonasal region. MATERIALS ANDMETHODS:
The study materials were 16 specimens of normal nasal mucosa, 16 inverted papillomas (IPs) and 12 sinonasal squamous cell carcinomas. The p53, p21, cyclin D1 and Ki-67 expression was assessed by immunohistochemical staining.RESULT:
IP and squamous cell carcinoma showed significant increase in the expression of p53, cyclin D1 and Ki-67 than normal mucosa. The expression of p53, cyclin D1 and Ki-67 of the carcinoma was stronger than the IP. But, the p21 expression was not associated with the IP and carcinoma.CONCLUSION:
Increased levels of p53, cyclin D1 and Ki-67 expression correlate with increased cell proliferation in the tumors of sinonasal regions. These findings indicate that p53, cyclin D1 and Ki-67 expression may be useful markers for the dysregulations of cell kinetics in the tumors of sinonasal region.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Kinetics
/
Carcinoma, Squamous Cell
/
Papilloma, Inverted
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Cyclin D1
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Cell Proliferation
/
Mucous Membrane
/
Nasal Mucosa
Language:
Korean
Journal:
Journal of Rhinology
Year:
2008
Document type:
Article