Two-Week Repeated Dose Toxicity of Atractylodis Rhizoma Alba in F344 Rats
Natural Product Sciences
; : 180-186, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-192320
Responsible library:
WPRO
ABSTRACT
This research is to estimate the toxicity of Atractylodis Rhizoma Alba (ARA) in F344 rats and to find a dose level for the 13 weeks toxicity study. A hot water extract of ARA (ARWE) was administered orally to F344 rats at dose levels of 0 (vehicle control), 500, 1000, 2000, 3500, and 5000 mg/kg/day for 2 weeks. Each group was composed to five male and five female F344 rats. According to the result, there were no ARWE-related adverse changes in mortality, body weights, food consumption, urinalysis, hematology, clinical chemistry, gross finding at necropsy, and organ weight examination. Salivation was observed in 3500 and 5000 mg/kg/day in male and female rats but it could not have found any relationship with ARWE administration. Based on our findings, ARWE may not cause toxicity in rats under the experimental conditions. Therefore, dose level of 5000 mg/kg/day as a highest treatment group in 13-week exposure study is recommended for further toxicity assessment.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Obesity
Database:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Rats, Inbred F344
/
Salivation
/
Body Weight
/
Water
/
Chemistry, Clinical
/
Mortality
/
Urinalysis
/
Toxicity Tests
/
Hematology
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Natural Product Sciences
Year:
2016
Document type:
Article